There are numerous applications for Polyethylenimines. They can be a component of everyday items such as detergents or cosmetics. However, there are also highly specialized applications in biology and pharmacology. Provided the necessary quality criteria are met. We at ChemCon are able to produce polymers in pharmaceutical quality. Some applications for Polyethyleneimines produced under GMP are
- Transfection agent for nucleic acids
- Binding promoter for cells
- Permeabilization of bacteria
PEI at ChemCon
For many years, polymer chemistry has been a discipline in which ChemCon has gained experience. Our polymer chemists are experts in their field and can work with you to synthesize a polymer according to your requirements. In the field of Polyethyleneimines and polyoxazolines, we are one of the few companies able to carry out syntheses under GMP conditions. This makes our polymers suitable for pharmaceutical applications. The product can be customized for your application. One of the advantages you have with ChemCon is the constant exchange from the development phase to GMP synthesis. We are the right partner for your project!
Customization
Various residual groups make polyoxazolines extremely flexible. We realize the right residual group for your application.
We can also adjust chain length, molecular weight distribution, degree of substitution, end groups and more.
Synthesis
Starting from Poly(2-ethyl-2-oxazoline), for example, the porpionyl group can be split off by adding hydrochloric acid. This produces linear Polyethyleneimine. Chain length and residues can be influenced by the reactants or modified process control.
Applications
Polyethylenimines are able to condense DNA into positively charged particles. These adhere to the anionic cell surface and from there they are transported into the cell by endocytosis. Once inside the cell, the protonation of the amines reduces the osmotic potential, causing the vesicles to swell, burst and release the polymer-DNA complex into the cytoplasm.
Polyethylenimines are used in cultures of weakly adherent cells to increase adhesion. As a cationic polymer, it attracts the negatively charged surfaces of cells. PEI can therefore be applied to various surfaces to anchor cell cultures to them.
PEI is able to increase the permiabilization of hydrophobic substances through the membrane of gram-negative bacteria.
Analytics
Our equipment includes a whole range of validated analytical methods. This enables us to carry out a large proportion of the analytical measurements required for characterization directly on our premises.
Our equipment includes
- GPC
- GPLC
- IR
- NMR
- and much more.
Downloads
Here you can find more information:
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